Aishwarya G. Nadadhur
|2013-||PhD candidate||Vrije University (VU) Amsterdam|
|2012||Research Assistant||Department of Medical biochemistry and biophysics (MBB), Karolinska Institute (KI), Stockholm, Sweden|
|2010-2012||Master of Science in Applied Biotechnology||Uppsala University (UU), Uppsala, Sweden|
|2005-2009||Bachelor of Technology in Biotechnology (Distinction)||Anna University (AU), Chennai, India|
Tuberous sclerosis is a rare, multiple organ disorder with developmental delays. It is caused by defects in either/ both of the 2 genes TSC1 and TSC2. Defects like cortical tubers, giant cell astrocytoma, etc in the brain lead to learning difficulties and affected individuals suffer from Autism. Earlier studies indicated that TSC patients show affected brain synchronization, defective excitatory/inhibitory neuron switch, and glial defects. What cell types are primarily affected by TSC mutations and what disease mechanism underlie the glial defects found is so far unknown. My goal is to study the neuronal and glial cell phenotypes in Tuberous sclerosis (TSC) patient-derived iPSCs.