Prisca Leferink

PhD student
Team Member

Short CV

2013-PhD candidateVU University Medical Center Amsterdam
2010‑2012Master of Science in NeurosciencesVU University Amsterdam
2009Senior TechnicianAffymetrix Gene Expression, ServiceXS, Leiden
2006‑2009Bachelor of Science in BiologyLeiden University

Research

In my PhD project I focus on Vanishing White Matter (VWM) disease, a genetic childhood brain disease. Clinical symptoms including spasticity and ataxia progress and eventually lead to death. Currently there is no treatment available. Central in the pathology of the disease is the loss of brain white matter, which is important for the transmission of nerve signals to the rest of the brain and the body. The glial cells in the white matter are affected in the VWM brain. Glial precursor cell transplantation might facilitate white matter repair. However, which glial cell type in the VWM brain should be replaced to get optimal recovery is not clear. During my PhD project I use induced pluripotent stem cells (iPSCs) to investigate the primary affected glial cell type, and to work towards a glial cell transplantation therapy for VWM.

Contact info

Address:

VU University
De Boelelaan 1085, W&N Bldg, Rm G350
1081 HV Amsterdam
The Netherlands

Telephone:

+31(0)20 5981820

E-mail:p.leferink@vumc.nl