Team Leader
Danielle Posthuma

Psychiatric & Statistical Genomics

Research in this group aims at elucidating underlying biological pathways of brain-related traits and translating these to modifiable targets that can aid in treating brain disorders. We integrate knowledge from different fields, including psychiatry, genetics, bioinformatics and mathematics.

Team Leader
Tinca Polderman

Psychiatric Etiology

On the role of Nature and Nurture in psychiatric traits.
The ‘Psychiatric Etiology’ group studies the role of nature and nurture, including their interaction, in psychiatric traits. ‘Why do certain individuals develop a disorder, and others not?’ Is it nature or nurture, or a combination of both?

Team Leader
Sophie van der Sluis

Phenotypic modelling in genetics

While twin- and family studies have shown that many traits are considerably heritable, the role of specific genes in heritable traits remains poorly understood and genes that are identified, only explain a small portion of the trait variance. The focus of this group is on modeling complex and dynamic traits in such a way that the probability to uncover the genetic basis is maximized.

Team Leader
Vivi Heine

Stem Cell Biology

Although a glial component in neurological disorders is increasingly appreciated, we still lack proper understanding of neuron-glia communications. Our goal is to identify and describe glial defects in neurodevelopmental disorders, and to perform proof-of-concept studies for glial-targeted therapy strategies using advanced stem cell technologies.

Team Leader
Philipp Koellinger


Our group investigates how genes influence economic behavior, and how insights into the genetic architecture of behavioral outcomes can inform social and medical research. We use big data, powerful computers, and advanced quantitative methods for our interdisciplinary work.