Research

Research in CTGlab explores the genetic and environmental causes of individual differences in brain-related health and disease. We integrate knowledge from different fields (genetics, neuroscience, bioinformatics, biology, machine learning), use and develop analytical tools to analyze and understand genomic data for complex traits, and connect to neuroscience to prove causation in wet-lab experiments.

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Research

Research in CTGlab explores the genetic and environmental causes of individual differences in brain-related health and disease. We integrate knowledge from different fields (genetics, neuroscience, bioinformatics, biology, machine learning), use and develop analytical tools to analyze and understand genomic data for complex traits, and connect to neuroscience to prove causation in wet-lab experiments.

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Videos

NWO Brain & Cognition has awarded CTGlab PhD students Anke Hammerschlag and Sabine Mous the first prize for best integrated project and the attractive joint presentation of their collaboration on “An Integrative Theory of the Genetically Mediated Neural Substrates of ADHD”.

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About Us

CTGlab was setup in 2008 by Danielle Posthuma as a small research group within the CNCR at the VU and the Amsterdam University Medical Centre. Since 2014 CTGlab is a sub-department of the CNCR and Amsterdam-UMC. We participate in Amsterdam Neuroscience.

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News

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Best Student Paper Award awarded to Ilan Libedinsky

The paper of CNCR researcher Ilan Libedinsky “Genetic timeline of human brain and cognitive traits” has been awarded the Best Student Paper Award at the 23rd annual conference of the International Society for Intelligence Research (ISIR), held in Berkeley, California, from July 27-29, 2023.
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Novel insights in cellular mechanisms of 4H Leukodystrophy

Dr. Stephanie Dooves, Liza Kok and colleagues performed a study aiming to enhance our understanding of the disease mechanisms behind 4H leukodystrophy. This study, performed under the supervision of Dr. Vivi Heine and Prof. Nicole Wolf, provides the first insights into the cellular mechanisms underlying 4H leukodystrophy.
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Exploring the genetic overlap among twelve psychiatric disorders

In a study published in Nature Genetics, Cato Romero, Mats Nagel, and Sophie van der Sluis teamed up with colleagues from the Complex Trait Genetics department and the Million Veteran Program to scrutinize the genetic similarity of twelve psychiatric disorders. Besides identifying shared genes and biological substrates between pairs of disorders, they also elucidated the challenges jeopardizing the future success of cross-trait genetic research.

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