Functional consequences of genes for intelligence

March 9, 2018


A joint effort between the groups of Gerome Breen of the Institute of Psychiatry, London and Danielle Posthuma of the CNCR-CTG, highlights functional consequences of genes associated with intelligence, published March 8, in Molecular Psychiatry.

Meta-analyzing two large, genetically informative cohorts (GWAS data on a population based cohort and a high intelligence cohort), the international group of researchers show that genes associated with intelligence implicate pyramidal neurons of the somatosensory cortex and CA1 region of the hippocampus, and midbrain embryonic GABAergic neurons. These results provide new hypotheses for neuroscience.

Read the full paper:

Jonathan R. I. Coleman, Julien Bryois, Héléna A. Gaspar, Philip R. Jansen, Jeanne E. Savage, Nathan Skene, Robert Plomin, Ana B. Muñoz-Manchado, Sten Linnarsson, Greg Crawford, Jens Hjerling-Leffler, Patrick F. Sullivan, Danielle Posthuma* & Gerome Breen*. Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals. Molecular Psychiatry (2018) doi:10.1038/s41380-018-0040-6