10/2012-current | Complex Trait Genetics, Department of Functional Genomics, CNCR, VU University Amsterdam | Position: PhD student | Project:
03/2012-09/2012 | Department of Clinical Genetics, Section Medical Genomics, VU Medical Center | Position: Research Assistant | Project: Data analysis of exome sequencing in PSP patients
06/2011-09/2011 | Department of Clinical Genetics, Section Medical Genomics, VU Medical Center | Position: Undergraduate Teaching Assistant | Project: DNA isolation
01/2011-05/2011 | Department of Clinical Genetics, Section Medical Genomics, VU Medical Center | Research internship | Project: Genetic characterization of Frontotemporal Dementia and Alzheimer’s Disease cohorts
02/2010-08/2010 | Gray Matter and Cognition Group, MS Center, VU Medical Center | Research internship | Project: fMRI analysis of episodic memory retrieval in MS patients
2009-2011 | VU University Amsterdam, Master of Neuroscience, cum laude | Specialization 2nd year: Medical and Behavioral Genetics
2006-2009 | VU University Amsterdam, Bachelor Psychology, cum laude | Specialization 3rd year: Biological Psychology
Functional gene networks in ADHD
Attention‐deficit Hyperactivity Disorder (ADHD) is a neurobehavioral developmental disorder affecting about 3‐7% of children worldwide. Twin and family studies have indicated that ADHD is highly heritable (~75%). Nevertheless, recent genome‐wide association studies (GWAS) failed to find significant associations at a genome‐wide level. These findings suggest that thousands of alleles, each of very small effect, contribute to the risk of ADHD. Research into the etiology of ADHD is in need of novel research methodologies that elucidate the genetic etiology and underlying biological pathways.
We propose to apply a novel method for defining functional gene networks (FGNs) according to shared cellular function. The main aim of my project is to identify FGNs associated with ADHD, and secondly, to test the relation of these gene networks with abnormalities in brain morphology related to ADHD. Combining FGN analysis with imaging data provides direct insight into the brain structures that are mediated by FGNs important for ADHD. The integrated imaging genomics design is realized together with a second PhD project on MRI in ADHD (Sabine Mous). Eventually we aim to formulate an integrated neurobiological theory of ADHD.
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