Emil Uffelmann
Short CV
2020 - present | PhD candidate | Vrije Universiteit Amsterdam |
2019 - 2020 | University Research Fellow | Vrije Universiteit Amsterdam |
2018 - present | M.Sc. Neuroscience | Vrije Universiteit Amsterdam |
2015 - 2018 | B.Sc. Psychology (Cum Laude) | University of Groningen |
Research
Current polygenic risk scores (PRSs) for psychiatric traits only moderately predict case-control status, and not all individuals with very high polygenic risk for e.g. schizophrenia are actually diagnosed with the condition. The reasons for such a discrepancy may be environmental in origin, or may be due to currently undetected genetic influences that counteract the polygenic risk, thus leading to a discrepancy between an individual’s phenotype and their PRS. We call such a discrepancy “dissonance of genetic risk”. My work explores dissonance-conferring variants for polygenic traits.
Highlighted publications
• Uffelmann, E. & Posthuma, D. Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal. Biol Psychiatry 89, 41–53 (2021).
Contact info
Address: | Vrije Universiteit Amsterdam |
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Telephone: | +31 20 598 31 83 |
E-mail: | e.uffelmann@vu.nl |