Emil Uffelmann

PhD student

Team Member

Short CV

2020 - present	PhD candidate	Vrije Universiteit Amsterdam
2019 - 2020	University Research Fellow	Vrije Universiteit Amsterdam
2018 - present	M.Sc. Neuroscience	Vrije Universiteit Amsterdam
2015 - 2018	B.Sc. Psychology (Cum Laude)	University of Groningen

Research

Current polygenic risk scores (PRSs) for psychiatric traits only moderately predict case-control status, and not all individuals with very high polygenic risk for e.g. schizophrenia are actually diagnosed with the condition. The reasons for such a discrepancy may be environmental in origin, or may be due to currently undetected genetic influences that counteract the polygenic risk, thus leading to a discrepancy between an individual’s phenotype and their PRS. We call such a discrepancy “dissonance of genetic risk”. My work explores dissonance-conferring variants for polygenic traits.

Highlighted publications

• Uffelmann, E. & Posthuma, D. Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal. Biol Psychiatry 89, 41–53 (2021).

Contact info

Address:	Vrije Universiteit Amsterdam Center for Neurogenomics and Cognitive Research (CNCR) Department of Complex Trait Genetics W&N building, Room B-644 De Boelelaan 1085 1081 HV Amsterdam The Netherlands
Telephone:	+31 20 598 31 83
E-mail:	e.uffelmann@vu.nl