|2020 - present||PhD candidate||Vrije Universiteit Amsterdam|
|2019 - 2020||University Research Fellow||Vrije Universiteit Amsterdam|
|2018 - present||M.Sc. Neuroscience||Vrije Universiteit Amsterdam|
|2015 - 2018||B.Sc. Psychology (Cum Laude)||University of Groningen|
Current polygenic risk scores (PRSs) for psychiatric traits only moderately predict case-control status, and not all individuals with very high polygenic risk for e.g. schizophrenia are actually diagnosed with the condition. The reasons for such a discrepancy may be environmental in origin, or may be due to currently undetected genetic influences that counteract the polygenic risk, thus leading to a discrepancy between an individual’s phenotype and their PRS. We call such a discrepancy “dissonance of genetic risk”. My work explores dissonance-conferring variants for polygenic traits.
• Uffelmann, E. & Posthuma, D. Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal. Biol Psychiatry 89, 41–53 (2021).
Vrije Universiteit Amsterdam
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