Emil Uffelmann

PhD student
Team Member

Short CV

2020 - presentPhD candidateVrije Universiteit Amsterdam
2019 - 2020 University Research FellowVrije Universiteit Amsterdam
2018 - present M.Sc. NeuroscienceVrije Universiteit Amsterdam
2015 - 2018B.Sc. Psychology (Cum Laude)University of Groningen


Current polygenic risk scores (PRSs) for psychiatric traits only moderately predict case-control status, and not all individuals with very high polygenic risk for e.g. schizophrenia are actually diagnosed with the condition. The reasons for such a discrepancy may be environmental in origin, or may be due to currently undetected genetic influences that counteract the polygenic risk, thus leading to a discrepancy between an individual’s phenotype and their PRS. We call such a discrepancy “dissonance of genetic risk”. My work explores dissonance-conferring variants for polygenic traits.

Highlighted publications

Uffelmann, E. & Posthuma, D. Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal. Biol Psychiatry 89, 41–53 (2021).

Contact info


Vrije Universiteit Amsterdam
Center for Neurogenomics and Cognitive Research (CNCR)
Department of Complex Trait Genetics
W&N building, Room B-644
De Boelelaan 1085
1081 HV Amsterdam
The Netherlands


+31 20 598 31 83