Emil Uffelmann

PhD student
Team Member

Short CV

2020 - presentPhD candidateVrije Universiteit Amsterdam
2019 - 2020 University Research FellowVrije Universiteit Amsterdam
2018 - present M.Sc. NeuroscienceVrije Universiteit Amsterdam
2015 - 2018B.Sc. Psychology (Cum Laude)University of Groningen

Research

Current polygenic risk scores (PRSs) for psychiatric traits only moderately predict case-control status, and not all individuals with very high polygenic risk for e.g. schizophrenia are actually diagnosed with the condition. The reasons for such a discrepancy may be environmental in origin, or may be due to currently undetected genetic influences that counteract the polygenic risk, thus leading to a discrepancy between an individual’s phenotype and their PRS. We call such a discrepancy “dissonance of genetic risk”. My work explores dissonance-conferring variants for polygenic traits.

Highlighted publications

Uffelmann, E. & Posthuma, D. Emerging Methods and Resources for Biological Interrogation of Neuropsychiatric Polygenic Signal. Biol Psychiatry 89, 41–53 (2021).

Contact info

Address:

Vrije Universiteit Amsterdam
Center for Neurogenomics and Cognitive Research (CNCR)
Department of Complex Trait Genetics
W&N building, Room B-644
De Boelelaan 1085
1081 HV Amsterdam
The Netherlands

Telephone:

+31 20 598 31 83

E-mail:e.uffelmann@vu.nl