|2013-||PhD candidate||VU University Medical Center Amsterdam|
|2010‑2012||Master of Science in Neurosciences||VU University Amsterdam|
|2009||Senior Technician||Affymetrix Gene Expression, ServiceXS, Leiden|
|2006‑2009||Bachelor of Science in Biology||Leiden University|
In my PhD project I focus on Vanishing White Matter (VWM) disease, a genetic childhood brain disease. Clinical symptoms including spasticity and ataxia progress and eventually lead to death. Currently there is no treatment available. Central in the pathology of the disease is the loss of brain white matter, which is important for the transmission of nerve signals to the rest of the brain and the body. The glial cells in the white matter are affected in the VWM brain. Glial precursor cell transplantation might facilitate white matter repair. However, which glial cell type in the VWM brain should be replaced to get optimal recovery is not clear. During my PhD project I use induced pluripotent stem cells (iPSCs) to investigate the primary affected glial cell type, and to work towards a glial cell transplantation therapy for VWM.