Sophie Lee

PhD student
Team Member

Short CV

2023 – present PhD candidate Amsterdam UMC / Vrije Universiteit Amsterdam
2021 – 2023 MSc Brain and Cognitive Science University of Amsterdam
2016 – 2021 MSci Neuroscience with Psychology University of Aberdeen


GRIN2B syndrome is a rare neurodevelopmental disorder resulting in severe developmental delays and treatment-resistant epilepsy. The broad clinical phenotypes of this population have hindered the identification of genotype-phenotype correlations for GRIN2B. Consequently, there remains a distinct lack of effective therapeutic strategies available for patients. To build upon recent work indicating that L-serine confers therapeutic benefit to some but not all GRIN2B patients, I will develop patient-specific, iPSC-derived model systems of GRIN2B syndrome. These model systems will be utilised to conduct n-of-1 trials to investigate underlying disease mechanisms and provide preclinical measures of therapeutic efficacy for L-serine and other drug candidates. This project thereby aims to (i) elevate our current understanding of GRIN2B pathophysiology, particularly in relation to neuron-glia interactions, and (ii) assist clinicians through provision of evidence-based treatment guidelines.

Highlighted publications


Contact info


Vrije Universiteit Amsterdam
Center for Neurogenomics and Cognitive Research (CNCR)
Department of Complex Trait Genetics
W&N building, G349
De Boelelaan 1085
1081 HV Amsterdam
The Netherlands


+31 20 598 51 81