|2011-||PhD candidate||VU University Amsterdam|
|2013||Visiting Research Scholar||Rowitch lab, UCSF, San Francisco, USA|
|2009‑2010||Exchange Honours Master Programme||VU University Amsterdam, Erasmus University Rotterdam and the Netherlands Institute for Neuroscience|
|2008‑2010||Master of Science in Neurosciences (cum laude)||VU University Amsterdam|
My PhD project is focused on Vanishing White Matter (VWM). VWM is a rare genetic brain disorder causing progressive neurological symptoms like ataxia and spasticity. VWM is fatal and no curative therapies are available. The oligodendrocytes and astrocytes in the bran white matter are mainly affected in VWM. We have identified astrocytes as a central player in the VWM disease development (Dooves et al., 2016, JCI), indicating that astrocytes are an important target in therapy development. Currently we are studying glial cell maturation in VWM using induced pluripotent stem cells, and the prospects for cell replacement therapy for VWM in combination with microenvironmental targeting strategies.
Dooves S, van der Knaap MS, Heine VM. Stem cell therapy for white matter disorders: don’t forget the microenvironment! J Inherit Metab Dis. 2016 Mar 21.
Dooves S#, Bugiani M#, Postma NL, Polder E, Land N, Horan ST, van Deijk AL, van de Kreeke A, Jacobs G, Vuong C, Klooster J, Kamermans M, Wortel J, Loos M, Wisse LE, Scheper GC, Abbink TE, Heine VM*, van der Knaap MS*. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016 Apr 1;126(4):1512-24.
# Shared first authorship *Shared senior authorship.
Heine VM, Dooves S, Holmes D, Wagner J. Induced Pluripotent Stem Cells in Brain Diseases. Understanding the Methods, Epigenetic Basis, and Applications for Regenerative Medicine. SpringerBriefs in Neurosciences. 2012, 2012, XV, 59 p. 7 illus., 6 in color.
+31 20 5981820