Data Cohorts & Consortia
CTGlab has initiated data collection of two large scale cohorts: NESCOG and ‘BinnensteBuiten’, and is partner in the ID1000 sample collection of the Spinoza Centre, where it is responsible for genetic analyses.
The Netherlands Study of Cognition, Genes and Environment (NESCOG) was set up to investigate the underlying genetic mechanisms of intelligence as well as to investigate potential interactions of genes with environmental factors relevant to intelligence.
The NESCOG study is a large-scaled, population based study in which more than 2000 adults and children have participated. From all individuals measures of cognitive behavior have been collected as well as questionnaires on environmental factors. From most adult individuals DNA has also been collected, and exome chip genotypes are available. Part of the NESCOG data collection has been carried out in collaboration with the science center NEMO as part of the Science Live exhibition .
The BinnensteBuiten study is carried out in collaboration with the Sophia Child Hospital of the Erasmus University Rotterdam, The Netherlands (Prof F Verhulst, drs G Dieleman). It includes 5000 children with a variety of child psychiatric diagnoses who were referred to the outpatient clinic of the Department of Child and Adolescent Psychiatry of the Erasmus University Medical Center, Rotterdam from 2001-13. The BinnensteBuiten study aims to identify risk factors for childhood psychopathology. Besides a psychiatric diagnosis, information on structured clinical interviews is available, as well as data on neurocognitive functioning, the Child Behavior Checklist and an extensive questionnaire including information on socio-economic status, ethnicity, life events, and other environmental factors. For 1700 children DNA has been collected and PsychChip genotypes will be available in 2015.
Together with the Dept of Adolescent Psychiatry at the VUMC (Prof Arne Popma & Jorim Tielbeek), CTGlab has initiated the BroadABC consortium, which aims to find genes for broad antisocial behavior. The current sample size is ±25,000 individuals for whom GWAS data is available. Besides population based cohorts, the consortium also includes forensic samples of prisoners and juvenile offenders.