Psychiatric Etiology



** Watanabe K, Stringer S, Frei O, Umićević Mirkov M, Polderman TJC, van der Sluis S, Andreassen O, Neale BM, Posthuma D (2019). The GWAS ATLAS: A global overview of pleiotropy and genetic architecture in complex traits. Nature Genetics, e-pub AUG 19
** Polderman TJC (2019). Editorial: The genetic overlap between cognitive abilities and a transdiagnostic vulnerability for psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, e-pub JULY 25
** Hammerschlag AR, de Leeuw C, Middeldorp CM, Polderman TJC (2019). Postsynaptic, neuron projection, and brain-expressed gene sets relate to the shared genetic risk across five psychiatric disorders. Psychological Medicine, e-pub JULY 25
** Jansen AG, Dieleman GC, Jansen PR, Verhulst FC, Posthuma D, Polderman TJC (2019). Associating psychiatric polygenic risk scores with neurodevelopmental disorders in a clinical child and adolescent sample. Behavior Genetics, e-pub JULY 11
** Clark DW, Okada Y, ……… Polderman TJC et al. Kubo M, Wilson JF (2019). Effects of autozygosity on a broad range of human phenotypes. Nature Communications, e-pub OCT 31
** Jansen PR, Watanabe K, Stringer S, Bryois J, Skene N, de Leeuw CA, Hammerschlag AR, Benjamins J, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T, Linnarson S, Sullivan PF, Smit AB, The 23andMe Research Team, Litterman N, Noblin L, Vacic V, van der Sluis S, Polderman TJC, Hjerling-Leffler J, van Someren EJW, Posthuma D (2019). Genome-wide Study of Insomnia (N=1,331,010) Identifies Novel Genetic Loci and Functional Pathways. Nature Genetics, 51, 394-403
** Alemany S, Jansen PR, Muetzel RL, Marqués N, El Marroun H, Jaddoe VW, Polderman TJC, Tiemeier H, Postuma D, White T (2019). Common polygenic variations for psychiatric disorders and cognition in relation to brain morphology in the general pediatric population. Journal of the American Academy of Child and Adolescent Psychiatry, 58, 600-607
** Liu M …, Jansen PR,…, Polderman TJC,…. et al Vrieze S (2019). Association studies of up to 1.2 million individuals yields new insights in the genetic etiology of tobacco and alcohol use. Nature Genetics, 51, 237-244
** Erzurumluoglu AM, …… Polderman TJC …. et al Liu DJ, Howson JMM (2019). Meta-analysis of up to 622,409 individuals identifies novel smoking behaviour associated genetic loci. Molecular Psychiatry, e-pub JAN 7
**Brazel DM…… Polderman TJC …. et al Vrieze S (2019). Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use. Biological Psychiatry, 85, 946-955.
** Jansen PR, Muetzel RL, Polderman TJC, Jaddoe VW, Verhulst FC, van der Lugt A, Tiemeier H, Posthuma D, White T (2019). Polygenic Scores for Neuropsychiatric Traits and White Matter Microstructure in the Pediatric Population. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4, 243-250


** Pettersson E, Lichtenstein P, Larsson H, Song J, Attention Deficit/Hyperactivity Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Autism Spectrum Disorder Working Group of the iPSYCH-Broad-PGC Consortium, Bipolar Disorder Working Group of the PGC, Eating Disorder Working Group of the PGC, Major Depressive Disorder Working Group of the PGC, Obsessive Compulsive Disorders and Tourette Syndrome Working Group of the PGC, Schizophrenia Working Group of the PGC + CLOZUK sample, Substance Use Disorder Working Group of the PGC, Argrawal A, Børglum AD, Bulik CM, Daly MJ, Davis LK, Demontis D, Edenberg HJ, Grove J, Gelernter J, Neale BM, Pardinas A, Stahl E, Walters JT, Walters R, Sullivan PF, Posthuma D, Polderman TJC (2018). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, e-pub, SEP 17
** Savage J, Jansen PRPolderman TJC …. et al. Postuma D (2018). GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence. Nature Genetics, 50, 912-919
** Nagel M, Jansen PR …… Polderman TJC …. et al. Van der Sluis, Posthuma (2018). GWAS Meta-Analysis of Neuroticism (N=449,484) Identifies Novel Genetic Loci and Pathways. Nature Genetics, 50, 920-927
** Marees A, Hammerschlag AR, Posthuma D…… Polderman TJC …… et al. Derks EM (2018). Exploring the role of rare exonic variants in alcohol and tobacco use. Drug and Alcohol Dependence, 188, 94-101
** Tielbeek JJ, Vink JM, Polderman TJC, Popma A, Posthuma D, Verweij KJH (2018). Genetic correlation of antisocial behaviour with alcohol, nicotine, and cannabis use. Drug and Alcohol Dependence, 187, 296-299
** Polderman TJC, Kreukels BPC, Irwig M, Beach L, Chan YM, Derks EM, Esteva I, Ehrenfeld J, Den Heijer M, Posthuma D, Raynor L, Tishelman A, Davis LK, on behalf of the International Gender Diversity Genomics Consortium (IGDGC) (2018). The biological contributions to gender identity: bringing data to the table. Behavior Genetics, 48, 95-108
**Turcot V, Lu Y…… Polderman TJC, Hammerschlag AR, …. Hirshhorn JN, Loos RJF (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity. Nature Genetics, 50, 26-41
*** Jansen PR, Polderman TJC, Bolhuis K, van der Ende J, Jaddoe, VJ, Verhulst FC, White T, Posthuma D, Tiemeier H (2018). Polygenic scores for Schizophrenia and educational attainment predict behaviour problems in early childhood in the general population. Journal of Child Psychology and Psychiatry, 59, 39-47


** Jansen PR, Dremmen M, van der Berg AS, Dekkers IA, Blanken LME, Muetzel RL, Bolhuis K, Mulder RM, Kocevska D, Jansen TA, Polderman TJC, Posthuma D, de Wit MY, Jaddoe VWV, Verhulst FC, Tiemeier H, van der Lugt A, White TJH (2017). Incidental findings on Brain Imaging in the General Pediatric Population. New England J of Medicine, 377, 1593-1595
** Jorim Tielbeek, Ada Johansson, Polderman TJC, Raitiainen R, Jansen PR, Taylor M, Burt A, Tiemeier H, Viding E, Plomin R, Martin NG, Beaver KM, Waldman I, Munafo M, Paunio T, Mous SE, Pappa I, De Leeuw C, Hammerschlag AR, Dick D, Faraone SV, Popma A, Medland SE, Posthuma D (2017). Meta-analyses of genome-wide association studies on antisocial behaviour reveal high polygenicity, sex specific effects and pleiotropy with educational attainment. JAMA Psychiatry, 74, 1242-1250
** Stringer S, Polderman TJC, Posthuma D (2017). Majority of human traits show no sex-specific genetic and environmental effects. Scientific Reports, 7:8688
*** Jansen AG, Dieleman GC, De Leeuw C, Goudriaan A, Verhage M, Smit, AB, Verheijen MHG, Verhulst FC, Polderman TJC, Posthuma D (2017). Common genetic variation in FMRP is associated with Autism Spectrum Disorders. European Journal of Human Genetics, 25, 863-868
** Van der Sluis S, Polderman TJC, Neale M, Verhulst FC, Posthuma D, Dieleman GC (2017). Sex differences and gender-biased measurement in childhood psychopathology: do findings from population-based cohorts generalize towards a clinical sample? International Journal of Methods in Psychiatric Research, 26, e1498


***Al-Itejawi Z, Tielbeek JJ, Polderman TJC, Buckholtz JW, Popma A (2016). The impact of stress during adolescence on the development of aggressive behavior. A systematic review on the role of the dopaminergic system in rodents. Neuroscience & Biobehavioral Reviews, e-pub 5 Nov
** Romero-Martínez A, Moya-Albiol L, Vinkhuyzen AAE, Polderman TJC (2016). Genetic and environmental contributions to the inverse association between specific autistic traits and experience seeking in adults Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171, 1190-1197
** Mous SE, White T, Muetzel RL, El Marroun H, Rijlaarsdam J, Polderman TJC, Jaddoe VW, Verhulst FC, Posthuma D, Tiemeier H (2016). Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity problems and executive functioning – a population-based pediatric neuroimaging study. Journal of Psychiatry & Neuroscience, e-pub
** Tielbeek JJ, Karlsson Linnér R, Beers K, Popma A, Posthuma D, Polderman TJC (2016). Meta-analysis of the Serotonin Transporter Promoter Variant (5-HTTLPR) in relation to adverse environment and antisocial behavior.. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 171, 748-760


** Polderman TJC, Benyamin B, De Leeuw CA, Sullivan PF, van Bochoven A, Visscher PM & Posthuma D (2015). Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nature Genetics, 47, 702-709**
Jansen A, Mous SE, White T, Posthuma D & Polderman TJC (2015). What twin studies tell us about the heritability of brain development, morphology and function: a review. Neuropsychology Review, 25, 27-46
** Mous SE, Schoemaker N, Blanken L, Thijssen S, van der Ende J, Polderman, TJC, Jaddoe, VW, Hofm an A, Verhulst FC, Tiemeier H, White T (2015). The association of gender, age and intelligence with neuropsychological functioning in young typically developing children – the Generation R study. Applied Neuropsychology Child, 6, 22-40
** Mous SE, Hammerschlag AR, Polderman TJC, Verhulst FC, Tiemeier H, Jaddoe VW, Hofman A, White T, Posthuma D (2015). Imaging Genetics of Inattention and Hyperactivity/Impulsivity Symptoms: Candidate Genetic Pathways and Basal Ganglia Structures. Journal of the American Academy of Child and Adolescent Psychiatry 54, 745-752


** Polderman TJC, Hoekstra, RA, Posthuma, D, Larsson H (2014). The co-occurrence of autistic and ADHD dimensions in adults: an etiological study in 17 779 twins. Translational Psychiatry, 4, e435; doi:10.1038/tp.2014.84,
** Hammerschlag AR, Polderman TJC, de Leeuw C, Tiemeier H, White T, Smit AB, Verhage M, Posthuma D (2014). Functional gene set analysis does not support a major role for synaptic functioning in Attention Deficit/Hyperactivity Disorder. Genes, 5(3), 604-614
** Mous SE, Muetzel RL, El Marroun H, Polderman, TJC, Jaddoe, VW, Hofman A, Verhulst FC, Tiemeier H, Posthuma D, White T (2014). Cortical thickness and Inattention/Hyperactivity symptoms in young children: A population based study. Psychological Medicine, 44, 3203-3213
** Lewis GJ, Bates T, Posthuma D & Polderman TJC (2014). Core dimensions of personality broadly account for the link from perceived social support to symptoms of depression and anxiety. Journal of Personality, 82, 329-239


** King CR, van der Sluis S, Polderman TJC, Toonen RF (2013). A closer look at FBXO41 as a Parkinson’s disease risk factor. Parkinsonism and Related Disorders, 19, 1175-76
** Romero-Martínez A, Polderman TJC, González-Bono E, & Moya-Albiol L (2013). Masculinization in parents of offspring with Autism Spectrum Disorders could be involved in comorbid ADHD symptoms. Journal of Attention Disorders, e-pub
** Posthuma D & Polderman TJC (2013). What have we learned from recent twin studies about the etiology of neurodevelopmental disorders? Current Opinion in Neurology, 26, 111-121
** Polderman TJC, Hoekstra RA, Vinkhuyzen AAE, Sullivan PF, van der Sluis S, & Posthuma D (2013). Attentional switching forms a genetic link between Attention Problems and autistic traits in adults. Psychological Medicine, 43, 1985-1996


** Bartels M, van Weegen FI, van Beijsterveldt CEM, Carlier M, Polderman TJC, Hoekstra RA, Boomsma DI (2012). The five factor model of personality and intelligence: A twin study on the relationship between the two constructs. Personality and Individual Differences, 53, 368-373
** Robbers SCC, van Oort FVA, Polderman TJC, Bartels M, Boomsma DI, Verhulst FC, Lubke GH & Huizink AC (2011). Trajectories of attention problems in childhood. European Child & Adolescent Psychiatry, 20, 419-427
** Polderman TJC, Huizink AC, Verhulst FC, van Beijsterveldt CEM, Boomsma DI & Bartels M (2011). A genetic study on ADHD symptoms and academic skills: results of a longitudinal study in twins. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 20, 22-34
** Polderman TJC, van DongenJ & Boomsma DI (2011). The relation between ADHD symptoms and fine motor control: a genetic study. Child Neuropsychology, 17, 138-150
** Lamb DJ, Middeldorp CM, Van Beijsterveldt CEM, Bartels M, Polderman TJC & Boomsma DI (2010). The heritability of anxious/depressive and withdrawn behavior is under age related change during adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 248-255
** Polderman TJC, Bartels M, Verhulst FC, Huizink AC, Van Beijsterveldt CEM & Boomsma DI (2010). No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study. Journal of Epidemiology and Community Health, 64, 36-40
** Polderman TJC, Boomsma DI, Bartels M, Verhulst FC, & Huizink AC (2010). Attention Problems and Academic Achievement during childhood: a systematic review of prospective studies. Acta Psychiatrica Scandinavica, 122, 271-284 [in top citation list of journal in 2012]
** Rebollo I, Polderman TJC, & Moya-Albiol L. (2010). Genética de la violencia humana. Revista de Neurología, 50, 533-540
** Bochdanovits Z, Gosso MF, van den Berg L, Rizzu P, Polderman TJC, Pardo LM, Houlihan L, Luciano M, Starr J, Harris S, Deary I, de Geus EJC, Boomsma DI, Heutink P & Posthuma, D (2009). A functional polymorphism under positive evolutionary selection in ADRB2 is associated with human intelligence with opposite effects in the young and the elderly. Behavior Genetics, 39, 15-23
** Estourgie-van Burk GF, Bartels M, Hoekstra RA, Polderman TJC, Delemarre-van de Waal HA & Boomsma DI (2009). A twin study of cognitive costs of low birth weight and catch-up growth. Journal of Pediatrics, 154, 29-32
** Polderman TJC, De Geus EJC, Hoekstra RA, Bartels M, Van Leeuwen M, Verhulst FC, Posthuma D & Boomsma DI (2009). Attention problems, inhibitory control and intelligence index overlapping genetic factors: A study in 9, 12 and 18 years old twins. Neuropsychology, 23, 381-391
** Boomsma DI, Van Beijsterveldt CEM, Beem AL, Hoekstra RA, Polderman TJC & Bartels M (2008). Intelligence and birth order in boys and girls. Intelligence, 36, 630-634
** Gosso MF, De Geus EJC, Polderman TJC, Boomsma DI, Heutink P & Posthuma D (2008). Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioning. European Journal of Human Genetics, 16, 1075-1082
** Gosso MF, De Geus EJC, Polderman TJC, Heutink P, Boomsma DI & Posthuma D (2008). Common variants underlying cognitive ability: further evidence for association between the SNAP-25 gene and cognition using a family-based study in two independent Dutch cohorts. Genes, Brain and Behavior, 7, 355-364
** Luciano M, Lind PA, Deary IJ, Payton T, Posthuma D, Butcher LM, Bochdanovits Z, Whalley LJ, Visscher PM, Harris SE, Polderman TJC, Davis OSP, Wright MJ, Starr JM, De Geus EJC, Bates TC, Montgomery GW, Boomsma DI, Martin NG & Plomin R (2008). Testing replication of a 5-SNP set for general cognitive ability in six population samples. European Journal of Human Genetics, 16, 1388-1395
** Van der Sluis, S., Derom, C., Thiery, E., Bartels, M., Polderman, T. J. C., De Geus, E. J. C., Dolan, C. V., Boomsma, D. I., & Posthuma, D. (2008). Sex differences on the WISC-R in Belgium and The Netherlands. Intelligence, 36, 48-67
** Bartels, M., van Beijsterveldt, C. E. M., Derks, E. M., Stroet, T. M., Polderman, T. J. C., Hudziak, J. J., & Boomsma, D. I. (2007). Young – Netherlands Twin Register (Y-NTR); A Longitudinal Multiple Informant Study of Problem Behavior. Twin Research and Human Genetics, 10, 3-11
** Gosso, F. M., De Geus, E. J. C, Polderman, T. J. C., Boomsma, D. I. Posthuma, D. & Heutink, P. (2007). Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. BMC Medical Genetics, 8:66
** Mekel-Bobrov, N., Posthuma, D., Gilbert, S. L., Lind, P., Gosso, M. F., Luciano, M., Harris, S.E., Bates, T. C., Polderman, T. J. C., Whalley, L. J., Fox, H., Starr, J. M., Evans, P. D., Montgomery, G. W., Fernandes, C., Heutink, P., Martin, N. G., Boomsma, D. I., Deary, I. J., Wright, M. J., De Geus, E. J. C., & Lahn, B. T. (2007). The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence. Human Molecular Genetics, 16, 600-608
** Polderman TJC, Derks EM, Hudziak JJ, Verhulst FC, Posthuma D & Boomsma DI (2007). Across the continuum of Attention Skills: A twin study of the SWAN ADHD rating scale. Journal of Child Psychology and Psychiatry, 48, 1080-1087
**Polderman TJC, Posthuma D, Stins JF, De Sonneville LMJ, Verhulst FC & Boomsma DI (2007). Longitudinal genetic analyses on executive functioning during childhood. Biological Psychology, 76, 11-20
** Stins JF, Polderman TJC, Boomsma DI & De Geus ECJ (2007). Conditional accuracy in response interference tasks: Evidence from the Eriksen flanker task and the spatial conflict task. Advances in Cognitive Psychology, 3, 409-417
** Gosso MF, De Geus EJC, Van Belzen M, Polderman TJC, Heutink P, Boomsma, D. I., & Posthuma, D. (2006). The SNAP-25 gene is related to intelligence: Evidence form a family based association study in two independent Dutch cohorts. Molecular Psychiatry, 11, 878-886
** Gosso MF, Van Belzen M, De Geus EJC, Polderman TJC, Heutink P, Boomsma DI, Posthuma D (2006). Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. Genes, Brain and Behavior, 5, 577-584
** Nieuwenhuis S, Stins JF, Posthuma D, Polderman TJC, Boomsma DI & De Geus EJC (2006). Accounting for sequential trial effects in the flanker task: Conflict adaptation or associative priming? Memory & Cognition, 34, 1260-1276
** Polderman, TJC, Gosso MF, Posthuma D, Heutink P, Van Beijsterveldt TCEM, Verhulst FC & Boomsma DI (2006). A longitudinal twin study on IQ performance, executive functioning, and attention problems during childhood and early adolescence. Acta Neurologica Belgica, 16, 191-207
** Polderman TJC, Posthuma D, De Sonneville LMJ, Verhulst FC & Boomsma DI (2006). Genetic analyses of teacher ratings of problem behavior in 5-year-old twins. Twin Research and Human Genetics, 9, 122-130
** Polderman TJC, Stins JF, Posthuma D, Gosso MF, Verhulst FC, Boomsma DI (2006). The phenotypic and genotypic relation between Working Memory Speed and Capacity. Intelligence, 34, 549-560
** Van den Berg SM, Setiawan A, Bartels, M, Polderman TJC, Van der Vaart, AW, Boomsma DI (2006). Individual differences in puberty onset in girls: Bayesian estimation of heritabilities and genetic correlations. Behavior Genetics, 36, 261-271
** Stins JF, De Sonneville LMJ, Groot AS, Polderman TJC, Van Baal CGM & Boomsma DI (2005). Heritability of selective attention and working memory in preschoolers. Behavior Genetics, 35, 407-416
** Stins JF, Polderman TJC, Boomsma DI & De Geus ECJ (2005). Response Interference and working memory in 12-year old children. Child Neuropsychology, 11, 191-201
** Stins JF, Tollenaar MS, Slaats-Willemse DIE, Buitelaar JK, Swaab-Barneveld H, Verhulst FC, Polderman JC & Boomsma DI (2005). Sustained attention and executive functioning performance in Attention-Deficit/Hyperactivity Disorder. Child Neuropsychology, 11, 285-294
** Stins JF, Van Baal CGM, Polderman TJC, Verhulst FC & Boomsma DI (2004). Heritability of Stroop and flanker performance in 12-year old children. BMC Neuroscience, 5:49
** Boomsma DI, Vink JV, Van Beijsterveldt CEM, de Geus, EJC, Beem AL, Mulder EJCM, Derks EM, Riese H, Willemsen AHM, Bartels, M, van den Berg M, Kupper HM, Polderman TJC, Posthuma D, Rietveld MJH, Stubbe JH, Knol LI, Stroet T & van Baal GCM (2002). Netherlands Twin Register: A focus on longitudinal research. Twin Research, 5, 401-406